Program
The conference will be covered by a special issue of Drug Discovery Today and a number of presentations will be selected based on submitted abstracts.
Download Program (pdf)
Oral presentations
The scientific program of the meeting will include 14 invited lectures. Based on the abstracts about 28 additional short talks will be selected (20 min including discussion).
Speakers are asked to prepare their presentation as a PowerPoint file and to save it on a CD-ROM or a USB-key, which should be handed over to the technician during the registration.
Poster presentations
The poster session will consist of about 60 contributions. Poster size will be announced later. Posters should be mounted on Wednesday, September 19th and will be accessible until Friday, September 21th, 2007. Poster size : please note that the posters have a maximum width of 100 cm and a maximum height of 120 cm.
DAY 1: Wednesday, September 19th
Coffee - Registration
[+] Session I: Insights in chemistry of CPPs
- Introduction8h30-8h45
- Peptide-based nanoparticles for ex-vivo and in vivo delivery of siRNA
G. Divita8h45-9h30
- Adaptation of Penetratin to Heterogeneous Membrane Environment
is the Driving Force of its Action. A Molecular Modeling Study
A. Polyansky9h30-9h50
- Small Molecule Mimics of Cell Penetrating Peptides, What Do They Bring to the Table ?
D. Selwood9h50-10h10
- Modifications in the Chemical Structure of cell-Penetrating Peptides:
Impact on cargo Delivery
F. Burlina10h10-10h30
Coffee break - Posters session
[+] Session I: Insights in chemistry of CPPs
- The Gates of Cells: the Rodin to Cells for Peptides and Oligonucleotides
J. Gariepy11h00-11h45
- Synthesis and In Vitro Effect of Oligoarginine Conjugates with Antitumor Drugs
Z. Bánóczi11h45-12h05
- DNA Binding Properties of the Cell-Penetrating Peptide HIV-1 TAT(47-57)
A. Ziegler12h05-12h25
Lunch
[+] Workshops
- Workshops #1: Analysis of cellular transduction of PTDs
- Workshops #2: CPPs and Peptide Design and synthesis
- Posters
Coffee break - Posters
[+] Session II: Mechanisms of CPPs & cellular uptake
- From Homeoproteins to Penetratin, and Vice Versa
A. Joliot17h00-17h45
- Biophysical Studies of Model Membrane Interactions
of Cell Penetrating Peptides
A. Gräslund17h45-18h15
- MPG-Nano-Structure Delivery of a Therapeutic Peptide Targeting
the Cell Cycle Regulatory Protein Cdk2
G. McMaster18h15-18h35
- Novel Insights into the Phosphorothioate-Stimulated delivery of siRNA
to Mammalian Cells: Relationship between Sub-Cellular Localization
and Biological Activity
G. Sczakiel18h35-18h55
Posters - End of session
[full day program]
DAY 2: Thursday, September 20th
Coffee
[+] Session II: Mechanisms of CPPs and cellular uptake
- Applications of Cell-Penetrating Peptides in Regulation of Gene Expression
U. Langel8h30-9h15
- Design and Structure-Activity of Arginine-Rich Cell Penetrating Peptides:
Applications to Splicing Correction by Steric-Block Oligonucleotides
B. Lebleu9h15-10h00
- Peptide Degradation is a Critical Determinant for Cell-Penetrating Peptide Uptake
C. Palm10h00-10h20
- Molecular and Cellular Aspects of a Rational Design of Cell-Permeant Proteins
F. Edenhofer,10h20-10h40
Coffee break - Posters
[+] Session II: Mechanisms of CPPs and cellular uptake
- Crossing the Greasy Rubicon: Signal Sequence Hydrophobic Region
as a Leading Edge Bypassing Endocytic Pathway
J. Hawiger11h10-11h55
- Sequence-Specific Methyltransferase-Induced Labelling (SMILing) of Plasmid DNA
as a New Tool to Study Cell Transfection
E. Weinhold11h55-12h15
- Cellular Uptake Mechanism of Cell-Penetrating Peptides and CPP-Modified Liposomes
M.M. Fretz,12h15-12h35
Lunch
[+] Workshops
- Workshops #3: Cellular targeting by modified PTDs
- Workshops #4: Delivery systems and toxicity
Coffee break - Posters
[+] Session III: New delivery systems for therapeutic molecules
- Intracellular and Organelle-Specific Delivery of Pharmaceutical Nanocarriers
V.P. Torchilin17h00-17h45
- Lipidic Formulations for Efficient In Vitro and In Vivo Protein Delivery
C. Weill17h45-18h05
- Cellular Delivery of ww-p53 using Adenoviral Capsid Proteins
A. Villegas-Mendez18h05-18h25
- Selective Transfection and Gene Delivery into Distinct Actively Proliferating Cells
Mediated by a Natural Snake Toxin and Derivates
M. Hayashi18h25-18h45
Posters - End of session
[full day program]
DAY 3: Friday, September 21th
Coffee
[+] Session III: New delivery systems for therapeutic molecules
- Macropinocytosis, TAT, and DRBDs: Delivery of Therapeutic siRNAs
S.F. Dowdy8h30-9h15
- Receptor-Mediated Targeting of Metastatic Melanoma with Radiolabeled DOTAalpha-MSH Analogs
J.P. Bapst9h15-9h35
- Synthesis of New Peptidic Vectors for Cancer Therapy and Tumour Imaging
S. Foillard,9h35-9h55
- Design of CPP Maurocalcine Analogues for Efficient In Vitro
and In Vivo Delivery of Cargoes
M. De Waard,9h55-10h15
- Tumour Homing Peptides
P. Laakkonen,10h15-10h35
Coffee break - Posters
[+] Session IV: In vivo applications of delivery systems
- Use of Optical Imaging for Detection, Medical Imaging
and Treatment of Cancer Using Tumour Targeted Peptides:
JL. Coll11h05-11h50
- Recombinant Bacterial Vector for Antigen Delivery: from the Proof of Concept
to the High Throughput T-cell Vaccine Design
M. Derouazi,11h50-12h10
- VDAC and Bak Recombinant Proteolliposomes Induce Apoptosis in Cancer Cell Lines
L. Liguori,12h10-12h30
Lunch
[+] Session IV: In vivo applications of delivery systems
- Intracellular Peptide/Protein Therapy of Inflammation and Autoimmunity:
From Toxic Shock to Juvenile Diabetes
J. Hawiger14h00-14h45
- Peptide-Based System for the In Vivo Delivery of Therapeutic siRNA
L. Crombez,14h45-15h05
- A Molecular Adapter Containing Cell Penetrating and Cleavable Peptides
Increases Efficacy of Targeted Toxins in Mice and Reduces Side Effects
H. Fuchs15h05-15h25
- Intracellular Processing and Apoptotic Activity of Disulfide and Thioether Linked
Cytochrome c-Oligoarginine Conjugates in HeLa Cells
J. Zaro15h25-15h45
- Title to be announced
B. Pertuiset15h45-16h00
Coffee break - Posters
[+] Session IV: In vivo applications of delivery systems
- Bax Inhibiting Peptides (BIPs) and Cell Penetrating Penta-peptides (CPP5s):
In Vivo and In Vitro Application and Mechanism of Cell Entry
S. Matsuyama17h00-17h20
- Inhibition of Allergic Airways Disease by Local Application of a Cell Penetrating
Dominant Negative STAT-6 Peptide
E. Fixman17h20-17h40
- KAI Pharmaceuticals: A Therapeutic Platform for Modulating Intracellular PKC
F. Karim17h40-18h00
- Conclusion
S.F. Dowdy18h45-19h00
Posters - End of session
Meeting dinner
[full day program]